(2 or 3)-decenoate (10:1n7 or n8) to stearidonate (18:4n3)

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
14
Beta (Ratio):
-0.421
Position:
74040136
SE (Ratio):
0.039
Effect Allele:
A
Z-score (Ratio):
-10.839
Reference Allele:
G
-log10(P):
-61.365
MAF:
0.029
Beta (Num):
-0.345
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.076
SE (Den):
0.043
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs689308

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
0.170
Position:
4127730
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
11.954
Reference Allele:
A
-log10(P):
-74.159
MAF:
0.316
Beta (Num):
0.158
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.012
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
ECI2 C6orf201 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid biosynthesis

Ratio Explanation:

The ratio reflects competing processes of fatty acid breakdown (numerator) and synthesis (denominator), potentially influenced by the activity of beta-oxidation enzymes like ECI2.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered ECI2 function, supported by pQTL data, likely impacts fatty acid oxidation, influencing the ratio and contributing to dyslipidemia and cholelithiasis, which are linked to abnormal lipid metabolism.3[1], 4[2], 5[3]

Phenotype Driver:

Gene-centric:ECI2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data