oleate/vaccenate (18:1) to dodecadienoate (12:2)*

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.141
Position:
151879761
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
10.586
Reference Allele:
G
-log10(P):
-58.625
MAF:
0.318
Beta (Num):
0.026
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.115
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs148925835

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
14
Beta (Ratio):
0.478
Position:
73282698
SE (Ratio):
0.061
Effect Allele:
G
Z-score (Ratio):
7.882
Reference Allele:
T
-log10(P):
-33.373
MAF:
0.010
Beta (Num):
0.099
Novel Locus:
Yes ✔️
SE (Num):
0.073
Beta (Den):
-0.379
SE (Den):
0.073
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RBM25 RGS6

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
14
Beta (Ratio):
0.640
Position:
74040136
SE (Ratio):
0.036
Effect Allele:
A
Z-score (Ratio):
17.659
Reference Allele:
G
-log10(P):
-159.013
MAF:
0.030
Beta (Num):
0.035
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.605
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, beta-oxidation.4[1], 5[2], 6[3], 7[4]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.8[1], 9[2], 10[3], 11[4]

Ratio Explanation:

The ratio may reflect altered mitochondrial fatty acid oxidation, where ACOT2 dysfunction could lead to accumulation of its substrates like oleoyl-CoA, affecting downstream metabolism.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A missense variant in ACOT2 could alter its function, leading to an imbalance in the ratio of oleate/vaccenate to dodecadienoate. This dysregulation of fatty acid metabolism by ACOT2 might be a contributing factor to phenotypes where lipid homeostasis is important.2[1], 3[2]

Phenotype Driver:

Gene-centric:ACOT2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data