linoleate (18:2n6) to dodecadienoate (12:2)*

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2999545

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.129
Position:
151904146
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
11.927
Reference Allele:
T
-log10(P):
-73.835
MAF:
0.389
Beta (Num):
0.013
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.116
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

Region: rs148925835

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.480
Position:
73282698
SE (Ratio):
0.052
Effect Allele:
G
Z-score (Ratio):
9.246
Reference Allele:
T
-log10(P):
-45.207
MAF:
0.010
Beta (Num):
0.101
Novel Locus:
Yes ✔️
SE (Num):
0.073
Beta (Den):
-0.379
SE (Den):
0.073
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RBM25 RGS6

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.637
Position:
74040136
SE (Ratio):
0.031
Effect Allele:
A
Z-score (Ratio):
20.533
Reference Allele:
G
-log10(P):
-214.048
MAF:
0.030
Beta (Num):
0.032
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.605
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs11541763;rs141600125

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.147
Position:
2301520
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
-10.050
Reference Allele:
G
-log10(P):
-53.046
MAF:
0.157
Beta (Num):
0.012
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.158
SE (Den):
0.021
No CNV overlap
rQTL cluster:
35
Reaction Distance:
NA
Closest Genes:
ECI1 RNPS1 AC009065.1 DNASE1L2 E4F1

Region: rs660560

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.093
Position:
4125941
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
-8.102
Reference Allele:
A
-log10(P):
-35.151
MAF:
0.315
Beta (Num):
-0.004
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.089
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
ECI2 C6orf201 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 8[2]

Ratio Explanation:

The ratio reflects beta-oxidation efficiency; linoleate (18:2n6) is a precursor to the downstream intermediate dodecadienoate (12:2) in a multi-step degradation pathway.9[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data provided; the genetic and metabolite data suggest a mechanism rooted in fatty acid mitochondrial beta-oxidation, but a phenotype link is missing.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data