(2 or 3)-decenoate (10:1n7 or n8) to cis-4-decenoate (10:1n6)*

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of cis-4-decenoate (10:1n6)*
Metabolite Accession: GCST90199893
Name: cis-4-decenoate (10:1n6)*
Hmdb Id: HMDB0004980
Super Pathway: NA
Sub Pathway: NA
Inchikey: XKZKQTCECFWKBN

Associated Genomic Regions

Region: rs12127402

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.295
Position:
76205643
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
22.837
Reference Allele:
C
-log10(P):
-264.112
MAF:
0.308
Beta (Num):
-0.031
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.327
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.386
Position:
151879761
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
29.917
Reference Allele:
G
-log10(P):
-451.145
MAF:
0.318
Beta (Num):
-0.023
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.409
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.429
Position:
74040136
SE (Ratio):
0.036
Effect Allele:
A
Z-score (Ratio):
-11.997
Reference Allele:
G
-log10(P):
-74.686
MAF:
0.029
Beta (Num):
-0.345
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.084
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs676683

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.156
Position:
4127253
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
11.858
Reference Allele:
C
-log10(P):
-73.012
MAF:
0.316
Beta (Num):
0.158
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.003
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
ECI2 C6orf201 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation11[1], 12[2], 13[3]

Ratio Explanation:

This ratio reflects activity within the mitochondrial fatty acid beta-oxidation pathway; accumulation of both metabolites, especially cis-4-decenoate, is a known marker for ACADM deficiency.14[1], 15[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data