Infomap Cluster 161

Metabolite Network

mQTL individually significant in locus
Novel rQTL
Known rQTL

Aggregated Cluster Evidence

Significant GTEx eQTL Colocalization (P-alpha < 5e-5)

Tissue Gene P(alpha) Associated Metabolites
Heart Left Ventricle NFATC3 1.10e-05 3-hydroxybutyroylglycine**3-hydroxyoctanoylcarnitine (1)hexanoylcarnitine (c6)
Whole Blood SLC7A6 1.54e-05 3-hydroxybutyroylglycine**3-hydroxyoctanoylcarnitine (1)hexanoylcarnitine (c6)
Thyroid PLA2G15 3.73e-05 3-hydroxybutyroylglycine**3-hydroxyoctanoylcarnitine (1)hexanoylcarnitine (c6)

Genomic Context

Displaying 47 SNPs on Chr 1 for Cluster 161.

Novel rQTL (▲)
Known rQTL (▲)

Cluster Summary

218

Metabolite Ratios (rQTLs)

77

Total Unique Metabolites

11

Unnamed Metabolites

Ratios in Cluster 161

Ratio Name Novel in Cluster Driven By
(2 or 3)-decenoate (10:1n7 or n8) to cis-4-decenoate (10:1n6)* No
(r)-3-hydroxybutyrylcarnitine to (s)-3-hydroxybutyrylcarnitine No
(s)-3-hydroxybutyrylcarnitine to 3-hydroxydecanoate No
(s)-3-hydroxybutyrylcarnitine to 5-dodecenoate (12:1n7) No
(s)-3-hydroxybutyrylcarnitine to 5-dodecenoylcarnitine (c12:1) No
(s)-3-hydroxybutyrylcarnitine to acetylcarnitine (c2) No
(s)-3-hydroxybutyrylcarnitine to caproate (6:0) No
(s)-3-hydroxybutyrylcarnitine to caprylate (8:0) No
(s)-3-hydroxybutyrylcarnitine to decanoylcarnitine (c10) No
(s)-3-hydroxybutyrylcarnitine to Hexanoylcarnitine No
(s)-3-hydroxybutyrylcarnitine to hexanoylglycine No
(s)-3-hydroxybutyrylcarnitine to laurylcarnitine No
(s)-3-hydroxybutyrylcarnitine to octanoylcarnitine (c8) No
(s)-3-hydroxybutyrylcarnitine to x-11478 No
(s)-3-hydroxybutyrylcarnitine to x-21607 No
(s)-3-hydroxybutyrylcarnitine to x-23680 No
10-undecenoate (11:1n1) to glutamine conjugate of c7h12o2* No
2-butenoylglycine to 5-dodecenoate (12:1n7) No
2-butenoylglycine to caproate (6:0) No
2-butenoylglycine to caprylate (8:0) No
2-butenoylglycine to hexanoylglycine No
2-butenoylglycine to n-acetylglycine No
2-butenoylglycine to x-11478 No
2-butenoylglycine to x-23680 No
2-hydroxyoctanoate to x-23680 No
3-hydroxybutyrate to 3-hydroxybutyroylglycine** No
3-hydroxybutyrate to glutamine conjugate of c6h10o2 (1)* No
3-hydroxybutyrate to glutamine conjugate of c6h10o2 (2)* No
3-hydroxybutyrate to glutamine conjugate of c7h12o2* No
3-hydroxybutyrate to hexanoylglutamine No
3-hydroxybutyroylglycine** to 5-dodecenoate (12:1n7) No
3-hydroxybutyroylglycine** to caproate (6:0) No
3-hydroxybutyroylglycine** to caprylate (8:0) No
3-hydroxybutyroylglycine** to decanoylcarnitine (c10) No
3-hydroxybutyroylglycine** to Hexanoylcarnitine No
3-hydroxybutyroylglycine** to hexanoylglycine No
3-hydroxybutyroylglycine** to n-acetylglycine No
3-hydroxybutyroylglycine** to octanoylcarnitine (c8) No
3-hydroxybutyroylglycine** to x-11478 No
3-hydroxybutyroylglycine** to x-21607 No
3-hydroxybutyroylglycine** to x-23680 No
3-hydroxydecanoylcarnitine to cis-4-decenoylcarnitine (c10:1) No
3-hydroxydecanoylcarnitine to decanoylcarnitine (c10) No
3-hydroxydecanoylcarnitine to nonanoylcarnitine (c9) No
3-hydroxydecanoylcarnitine to octanoylcarnitine (c8) No
3-hydroxyhexanoylcarnitine (1) to (r)-3-hydroxybutyrylcarnitine No
3-hydroxyhexanoylcarnitine (1) to 3-hydroxybutyrate No
3-hydroxyhexanoylcarnitine (1) to 3-hydroxydecanoate No
3-hydroxyhexanoylcarnitine (1) to 3-hydroxylaurate No
3-hydroxyhexanoylcarnitine (1) to 5-dodecenoate (12:1n7) No
3-hydroxyhexanoylcarnitine (1) to 5-dodecenoylcarnitine (c12:1) No
3-hydroxyhexanoylcarnitine (1) to acetylcarnitine (c2) No
3-hydroxyhexanoylcarnitine (1) to adipoylcarnitine (c6-dc) No
3-hydroxyhexanoylcarnitine (1) to branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* No
3-hydroxyhexanoylcarnitine (1) to caproate (6:0) No
3-hydroxyhexanoylcarnitine (1) to caprylate (8:0) No
3-hydroxyhexanoylcarnitine (1) to cis-3,4-methyleneheptanoylglycine No
3-hydroxyhexanoylcarnitine (1) to cis-4-decenoate (10:1n6)* No
3-hydroxyhexanoylcarnitine (1) to cis-4-decenoylcarnitine (c10:1) No
3-hydroxyhexanoylcarnitine (1) to decanoylcarnitine (c10) No
3-hydroxyhexanoylcarnitine (1) to dodecenedioate (c12:1-dc)* No
3-hydroxyhexanoylcarnitine (1) to Hexanoylcarnitine No
3-hydroxyhexanoylcarnitine (1) to hexanoylglutamine No
3-hydroxyhexanoylcarnitine (1) to hexanoylglycine No
3-hydroxyhexanoylcarnitine (1) to laurylcarnitine No
3-hydroxyhexanoylcarnitine (1) to nonanoylcarnitine (c9) No
3-hydroxyhexanoylcarnitine (1) to octadecanedioate (c18-dc) No
3-hydroxyhexanoylcarnitine (1) to octanoylcarnitine (c8) No
3-hydroxyhexanoylcarnitine (1) to sebacate (c10-dc) No
3-hydroxyhexanoylcarnitine (1) to x-11478 No
3-hydroxyhexanoylcarnitine (1) to x-18886 No
3-hydroxyhexanoylcarnitine (1) to x-18921 No
3-hydroxyhexanoylcarnitine (1) to x-21353 No
3-hydroxyhexanoylcarnitine (1) to x-21607 No
3-hydroxyhexanoylcarnitine (1) to x-21736 No
3-hydroxyhexanoylcarnitine (1) to x-21829 No
3-hydroxyhexanoylcarnitine (1) to x-23680 No
3-hydroxylaurate to (s)-3-hydroxybutyrylcarnitine No
3-hydroxylaurate to glutamine conjugate of c6h10o2 (2)* No
3-hydroxylaurate to glutamine conjugate of c7h12o2* No
3-hydroxyoctanoylcarnitine (1) to cis-4-decenoylcarnitine (c10:1) No
3-hydroxyoctanoylcarnitine (1) to decanoylcarnitine (c10) No
3-hydroxyoctanoylcarnitine (1) to Hexanoylcarnitine No
3-hydroxyoctanoylcarnitine (1) to nonanoylcarnitine (c9) No
3-hydroxyoctanoylcarnitine (1) to octanoylcarnitine (c8) No
3-hydroxyoctanoylcarnitine (2) to decanoylcarnitine (c10) No
3-hydroxyoctanoylcarnitine (2) to octanoylcarnitine (c8) No
4-methylhexanoylglutamine to (s)-3-hydroxybutyrylcarnitine No
4-methylhexanoylglutamine to 2-butenoylglycine No
4-methylhexanoylglutamine to 3-hydroxybutyroylglycine** No
4-methylhexanoylglutamine to 3-hydroxyhexanoylcarnitine (1) No
4-methylhexanoylglutamine to gamma-glutamylglycine No
4-methylhexanoylglutamine to glutamine conjugate of c6h10o2 (1)* No
4-methylhexanoylglutamine to glutamine conjugate of c6h10o2 (2)* No
4-methylhexanoylglutamine to glutamine conjugate of c7h12o2* No
4-methylhexanoylglutamine to trans-2-hexenoylglycine No
4-methylhexanoylglutamine to x-12101 No
4-methylhexanoylglutamine to x-12839 No
5-dodecenoylcarnitine (c12:1) to 2-butenoylglycine No
5-dodecenoylcarnitine (c12:1) to 3-hydroxybutyroylglycine** No
5-dodecenoylcarnitine (c12:1) to glutamine conjugate of c6h10o2 (1)* No
5-dodecenoylcarnitine (c12:1) to glutamine conjugate of c6h10o2 (2)* No
5-dodecenoylcarnitine (c12:1) to glutamine conjugate of c7h12o2* No
5-dodecenoylcarnitine (c12:1) to x-12839 Yes
acetylcarnitine (c2) to Hexanoylcarnitine No
adipoylcarnitine (c6-dc) to (s)-3-hydroxybutyrylcarnitine No
adipoylcarnitine (c6-dc) to x-12101 No
branched-chain, straight-chain, or cyclopropyl 10:1 fatty acid (1)* to glutamine conjugate of c7h12o2* No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to (s)-3-hydroxybutyrylcarnitine No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 2-butenoylglycine No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 3-hydroxybutyroylglycine** No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to glutamine conjugate of c6h10o2 (1)* No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to glutamine conjugate of c6h10o2 (2)* No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to glutamine conjugate of c7h12o2* No
branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to x-12839 Yes
caproate (6:0) to x-12101 No
caprylate (8:0) to x-12101 No
cis 3,4-methyleneheptanoate to x-11478 Yes
cis 3,4-methyleneheptanoate to x-18921 No
cis-3,4-methyleneheptanoylcarnitine to x-23680 No
cis-3,4-methyleneheptanoylglycine to (s)-3-hydroxybutyrylcarnitine No
cis-3,4-methyleneheptanoylglycine to 2-butenoylglycine No
cis-3,4-methyleneheptanoylglycine to 3-hydroxybutyroylglycine** No
cis-3,4-methyleneheptanoylglycine to gamma-glutamylglycine Yes
cis-3,4-methyleneheptanoylglycine to glutamine conjugate of c6h10o2 (1)* No
cis-3,4-methyleneheptanoylglycine to glutamine conjugate of c6h10o2 (2)* No
cis-3,4-methyleneheptanoylglycine to glutamine conjugate of c7h12o2* No
cis-3,4-methyleneheptanoylglycine to glycine Yes
cis-3,4-methyleneheptanoylglycine to trans-2-hexenoylglycine Yes
cis-3,4-methyleneheptanoylglycine to x-12101 No
cis-4-decenoate (10:1n6)* to (s)-3-hydroxybutyrylcarnitine No
cis-4-decenoate (10:1n6)* to 3-hydroxybutyroylglycine** No
cis-4-decenoate (10:1n6)* to dodecadienoate (12:2)* No
cis-4-decenoate (10:1n6)* to glutamine conjugate of c6h10o2 (1)* No
cis-4-decenoate (10:1n6)* to glutamine conjugate of c6h10o2 (2)* No
cis-4-decenoate (10:1n6)* to glutamine conjugate of c7h12o2* No
cis-4-decenoate (10:1n6)* to linolenate [alpha or gamma; (18:3n3 or 6)] No
cis-4-decenoate (10:1n6)* to myristoleoylcarnitine (c14:1)* No
cis-4-decenoate (10:1n6)* to tetradecadienoate (14:2)* No
cis-4-decenoate (10:1n6)* to x-12101 No
cis-4-decenoate (10:1n6)* to x-21353 No
cis-4-decenoylcarnitine (c10:1) to (s)-3-hydroxybutyrylcarnitine No
cis-4-decenoylcarnitine (c10:1) to 3-hydroxybutyroylglycine** No
cis-4-decenoylcarnitine (c10:1) to glutamine conjugate of c6h10o2 (1)* No
cis-4-decenoylcarnitine (c10:1) to glutamine conjugate of c6h10o2 (2)* No
cis-4-decenoylcarnitine (c10:1) to glutamine conjugate of c7h12o2* No
cis-4-decenoylcarnitine (c10:1) to laurylcarnitine No
cis-4-decenoylcarnitine (c10:1) to linolenoylcarnitine (c18:3)* No
cis-4-decenoylcarnitine (c10:1) to myristoleoylcarnitine (c14:1)* No
cis-4-decenoylcarnitine (c10:1) to x-12101 No
decanoylcarnitine (c10) to myristoylcarnitine (c14) No
decanoylcarnitine (c10) to x-12101 No
dodecenedioate (c12:1-dc)* to glutamine conjugate of c6h10o2 (1)* No
dodecenedioate (c12:1-dc)* to glutamine conjugate of c6h10o2 (2)* No
dodecenedioate (c12:1-dc)* to glutamine conjugate of c7h12o2* No
gamma-glutamylglycine to caprylate (8:0) No
gamma-glutamylglycine to n-acetylglycine Yes
gamma-glutamylglycine to x-23680 No
glutamine conjugate of c6h10o2 (1)* to 3-hydroxydecanoate No
glutamine conjugate of c6h10o2 (1)* to 5-dodecenoate (12:1n7) No
glutamine conjugate of c6h10o2 (1)* to caproate (6:0) No
glutamine conjugate of c6h10o2 (1)* to caprylate (8:0) No
glutamine conjugate of c6h10o2 (1)* to decanoylcarnitine (c10) No
glutamine conjugate of c6h10o2 (1)* to Hexanoylcarnitine No
glutamine conjugate of c6h10o2 (1)* to hexanoylglycine No
glutamine conjugate of c6h10o2 (1)* to laurylcarnitine No
glutamine conjugate of c6h10o2 (1)* to octanoylcarnitine (c8) No
glutamine conjugate of c6h10o2 (1)* to x-11478 No
glutamine conjugate of c6h10o2 (1)* to x-21607 No
glutamine conjugate of c6h10o2 (1)* to x-23680 No
glutamine conjugate of c6h10o2 (2)* to 3-hydroxydecanoate No
glutamine conjugate of c6h10o2 (2)* to 3-hydroxymyristate No
glutamine conjugate of c6h10o2 (2)* to 5-dodecenoate (12:1n7) No
glutamine conjugate of c6h10o2 (2)* to acetylcarnitine (c2) No
glutamine conjugate of c6h10o2 (2)* to caproate (6:0) No
glutamine conjugate of c6h10o2 (2)* to caprylate (8:0) No
glutamine conjugate of c6h10o2 (2)* to decanoylcarnitine (c10) No
glutamine conjugate of c6h10o2 (2)* to dodecadienoate (12:2)* No
glutamine conjugate of c6h10o2 (2)* to hexadecadienoate (16:2n6) No
glutamine conjugate of c6h10o2 (2)* to Hexanoylcarnitine No
glutamine conjugate of c6h10o2 (2)* to hexanoylglycine No
glutamine conjugate of c6h10o2 (2)* to laurylcarnitine No
glutamine conjugate of c6h10o2 (2)* to margarate (17:0) No
glutamine conjugate of c6h10o2 (2)* to n-acetylglycine No
glutamine conjugate of c6h10o2 (2)* to octadecanedioate (c18-dc) No
glutamine conjugate of c6h10o2 (2)* to octanoylcarnitine (c8) No
glutamine conjugate of c6h10o2 (2)* to stearate (18:0) No
glutamine conjugate of c6h10o2 (2)* to x-11478 No
glutamine conjugate of c6h10o2 (2)* to x-21607 No
glutamine conjugate of c6h10o2 (2)* to x-23680 No
glutamine conjugate of c7h12o2* to 10-heptadecenoate (17:1n7) No
glutamine conjugate of c7h12o2* to 10-nonadecenoate (19:1n9) No
glutamine conjugate of c7h12o2* to 3-hydroxydecanoate No
glutamine conjugate of c7h12o2* to 3-hydroxymyristate No
glutamine conjugate of c7h12o2* to 5-dodecenoate (12:1n7) No
glutamine conjugate of c7h12o2* to caprate (10:0) No
glutamine conjugate of c7h12o2* to caproate (6:0) No
glutamine conjugate of c7h12o2* to caprylate (8:0) No
glutamine conjugate of c7h12o2* to decanoylcarnitine (c10) No
glutamine conjugate of c7h12o2* to hexadecadienoate (16:2n6) No
glutamine conjugate of c7h12o2* to Hexanoylcarnitine No
glutamine conjugate of c7h12o2* to hexanoylglycine No
glutamine conjugate of c7h12o2* to laurylcarnitine No
glutamine conjugate of c7h12o2* to margarate (17:0) No
glutamine conjugate of c7h12o2* to myristate (14:0) No
glutamine conjugate of c7h12o2* to n-acetylglycine No
glutamine conjugate of c7h12o2* to octadecanedioate (c18-dc) No
glutamine conjugate of c7h12o2* to octanoylcarnitine (c8) No
glutamine conjugate of c7h12o2* to palmitate (16:0) No
glutamine conjugate of c7h12o2* to pentadecanoate (15:0) No
glutamine conjugate of c7h12o2* to stearate (18:0) No
glutamine conjugate of c7h12o2* to x-11478 No
glutamine conjugate of c7h12o2* to x-21607 No
glutamine conjugate of c7h12o2* to x-23680 No
hexanoylglutamine to (s)-3-hydroxybutyrylcarnitine No
hexanoylglutamine to 2-butenoylglycine No
hexanoylglutamine to 3-hydroxybutyroylglycine** No
hexanoylglutamine to 3-hydroxyhexanoate No
hexanoylglutamine to glutamine conjugate of c6h10o2 (1)* No
hexanoylglutamine to glutamine conjugate of c6h10o2 (2)* No
hexanoylglutamine to glutamine conjugate of c7h12o2* No
hexanoylglutamine to myristoleoylcarnitine (c14:1)* No
hexanoylglutamine to palmitoleoylcarnitine (c16:1)* No
hexanoylglutamine to trans-2-hexenoylglycine No
hexanoylglutamine to x-12101 No
hexanoylglutamine to x-12839 No
hexanoylglycine to gamma-glutamylglycine No
hexanoylglycine to glycine No
hexanoylglycine to x-12101 No
laurylcarnitine to decanoylcarnitine (c10) No
laurylcarnitine to Hexanoylcarnitine No
laurylcarnitine to octanoylcarnitine (c8) No
linoleate (18:2n6) to cis-4-decenoate (10:1n6)* No
linolenoylcarnitine (c18:3)* to x-21607 No
myristoleate (14:1n5) to glutamine conjugate of c7h12o2* No
myristoleoylcarnitine (c14:1)* to decanoylcarnitine (c10) No
myristoleoylcarnitine (c14:1)* to Hexanoylcarnitine No
myristoleoylcarnitine (c14:1)* to octanoylcarnitine (c8) No
myristoylcarnitine (c14) to Hexanoylcarnitine No
n-acetylglycine to glycine Yes
nonanoylcarnitine (c9) to (s)-3-hydroxybutyrylcarnitine No
nonanoylcarnitine (c9) to 3-hydroxybutyroylglycine** No
nonanoylcarnitine (c9) to glutamine conjugate of c6h10o2 (1)* No
nonanoylcarnitine (c9) to glutamine conjugate of c6h10o2 (2)* No
nonanoylcarnitine (c9) to glutamine conjugate of c7h12o2* No
nonanoylcarnitine (c9) to laurylcarnitine No
nonanoylcarnitine (c9) to myristoleoylcarnitine (c14:1)* No
nonanoylcarnitine (c9) to myristoylcarnitine (c14) No
nonanoylcarnitine (c9) to x-12101 No
octanoylcarnitine (c8) to myristoylcarnitine (c14) No
octanoylcarnitine (c8) to x-12101 No
palmitoleoylcarnitine (c16:1)* to decanoylcarnitine (c10) No
palmitoleoylcarnitine (c16:1)* to Hexanoylcarnitine No
palmitoleoylcarnitine (c16:1)* to octanoylcarnitine (c8) No
sebacate (c10-dc) to (s)-3-hydroxybutyrylcarnitine No
sebacate (c10-dc) to 2-butenoylglycine No
sebacate (c10-dc) to 3-hydroxybutyroylglycine** No
sebacate (c10-dc) to glutamine conjugate of c6h10o2 (1)* No
sebacate (c10-dc) to glutamine conjugate of c6h10o2 (2)* No
sebacate (c10-dc) to glutamine conjugate of c7h12o2* No
tetradecadienoate (14:2)* to decanoylcarnitine (c10) No
tetradecadienoate (14:2)* to Hexanoylcarnitine No
tetradecadienoate (14:2)* to octanoylcarnitine (c8) No
trans-2-hexenoylglycine to hexanoylglycine No
trans-2-hexenoylglycine to n-acetylglycine Yes
tridecenedioate (c13:1-dc)* to glutamine conjugate of c7h12o2* No
x-11478 to x-12101 No
x-12101 to x-21607 No
x-12101 to x-23680 No
x-18886 to (s)-3-hydroxybutyrylcarnitine No Denominator
x-18886 to glutamine conjugate of c6h10o2 (1)* No
x-18886 to glutamine conjugate of c6h10o2 (2)* No
x-18886 to glutamine conjugate of c7h12o2* No
x-18921 to (s)-3-hydroxybutyrylcarnitine No
x-18921 to 2-butenoylglycine No
x-18921 to 3-hydroxybutyroylglycine** No
x-18921 to gamma-glutamylglycine No
x-18921 to glutamine conjugate of c6h10o2 (1)* No
x-18921 to glutamine conjugate of c6h10o2 (2)* No
x-18921 to glutamine conjugate of c7h12o2* No
x-18921 to linolenoylcarnitine (c18:3)* No
x-18921 to x-12101 No
x-21319 to x-11478 Yes
x-21319 to x-18921 No
x-21353 to (s)-3-hydroxybutyrylcarnitine No
x-21353 to glutamine conjugate of c6h10o2 (2)* No
x-21353 to glutamine conjugate of c7h12o2* No
x-21736 to (s)-3-hydroxybutyrylcarnitine No
x-21736 to 2-butenoylglycine No
x-21736 to 3-hydroxybutyroylglycine** No
x-21736 to glutamine conjugate of c6h10o2 (1)* No
x-21736 to glutamine conjugate of c6h10o2 (2)* No
x-21736 to glutamine conjugate of c7h12o2* No
x-21736 to x-12101 No
x-21829 to (s)-3-hydroxybutyrylcarnitine No
x-21829 to 2-butenoylglycine No
x-21829 to 3-hydroxybutyroylglycine** No
x-21829 to glutamine conjugate of c6h10o2 (1)* No
x-21829 to glutamine conjugate of c6h10o2 (2)* No
x-21829 to glutamine conjugate of c7h12o2* No
x-21829 to x-12101 No