branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 2-butenoylglycine

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 2-butenoylglycine
Metabolite Accession: GCST90200152
Name: 2-butenoylglycine
Hmdb Id: HMDB0341232
Super Pathway: NA
Sub Pathway: NA
Inchikey: WWJXRJJBIVSSNF

Associated Genomic Regions

Region: rs35630725;rs1890452

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.194
Position:
76192508
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
-9.342
Reference Allele:
G
-log10(P):
-46.104
MAF:
0.337
Beta (Num):
-0.068
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.125
SE (Den):
0.018
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Beta-Oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Acylglycine Formation, Fatty Acid Metabolism.6[1]

Ratio Explanation:

A higher ratio suggests decreased ACADM activity, causing accumulation of its substrate (C12:1 fatty acid) relative to downstream byproducts like those leading to 2-butenoylglycine.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data