dodecenedioate (c12:1-dc)* to glutamine conjugate of c6h10o2 (1)*

Numerator Metabolite

Structure of dodecenedioate (c12:1-dc)*
Metabolite Accession: GCST90200159
Name: dodecenedioate (c12:1-dc)*
Hmdb Id: HMDB0000933
Super Pathway: NA
Sub Pathway: NA
Inchikey: MAZWDMBCPDUFDJ

Denominator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7556201

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.186
Position:
76180586
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-10.466
Reference Allele:
T
-log10(P):
-57.356
MAF:
0.336
Beta (Num):
-0.048
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.139
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.1[1]

Denominator Metabolite Explanation:

Unknown.

Ratio Explanation:

A higher ratio may suggest altered fatty acid oxidation by ACADM, impacting the levels of dodecenedioate relative to the glutamine conjugate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The ACADM gene, involved in fatty acid metabolism, is linked to this ratio.1[1], 4[2], 5[3] While a direct link to a phenotype is not specified, altered fatty acid metabolism is associated with various metabolic disorders.

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data