cis-4-decenoylcarnitine (c10:1) to glutamine conjugate of c7h12o2*

Numerator Metabolite

Structure of cis-4-decenoylcarnitine (c10:1)
Metabolite Accession: GCST90199880
Name: cis-4-decenoylcarnitine (c10:1)
Hmdb Id: HMDB0013205
Super Pathway: NA
Sub Pathway: NA
Inchikey: GOOOCIIXFLVRAG

Denominator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs61797339

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.499
Position:
76189946
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
-26.569
Reference Allele:
G
-log10(P):
-356.462
MAF:
0.308
Beta (Num):
-0.391
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.108
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Mitochondrial fatty acid beta-oxidation.1[1]

Denominator Metabolite Explanation:

Glutamine metabolism, detoxification.5[1], 6[2]

Ratio Explanation:

An elevated ratio reflects impaired ACADM activity, leading to increased cis-4-decenoylcarnitine (a beta-oxidation intermediate) relative to a product of glutamine conjugation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype was provided in the input data, so a link between the gene, metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data