hexanoylglutamine to 3-hydroxybutyroylglycine**

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Metabolite Accession: GCST90200174
Name: 3-hydroxybutyroylglycine**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7539246

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.441
Position:
76203850
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
-25.858
Reference Allele:
C
-log10(P):
-337.795
MAF:
0.307
Beta (Num):
-0.285
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.156
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, glutamine conjugation.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, acyl glycine metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

An elevated ratio of hexanoylglutamine to 3-hydroxybutyroylglycine suggests impaired ACADM function, leading to accumulation of upstream hexanoyl-CoA (detoxified to hexanoylglutamine) versus downstream products.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in ACADM impair its enzymatic role in fatty acid oxidation, altering the ratio of hexanoylglutamine to 3-hydroxybutyroylglycine. No associated phenotype was provided, so a complete causal link cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data