glutamine conjugate of c6h10o2 (2)* to 3-hydroxymyristate

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxymyristate
Metabolite Accession: GCST90199674
Name: 3-hydroxymyristate
Hmdb Id: HMDB0061656,HMDB0010731
Super Pathway: NA
Sub Pathway: NA
Inchikey: ATRNZOYKSNPPBF

Associated Genomic Regions

Region: rs35630725;rs1890452

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.172
Position:
76192508
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
10.201
Reference Allele:
G
-log10(P):
-54.583
MAF:
0.337
Beta (Num):
0.129
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.043
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs2999541

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.131
Position:
151898749
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
7.872
Reference Allele:
C
-log10(P):
-33.291
MAF:
0.375
Beta (Num):
0.056
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.075
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism

Denominator Metabolite Explanation:

Fatty acid metabolism

Ratio Explanation:

The ratio may reflect a shift between xenobiotic detoxification and fatty acid oxidation, potentially influenced by ACADM and THEM4 activity on shared acyl-CoA substrates.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data