glutamine conjugate of c6h10o2 (2)* to octanoylcarnitine (c8)

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of octanoylcarnitine (c8)
Metabolite Accession: GCST90199720
Name: octanoylcarnitine (c8)
Hmdb Id: HMDB0000791
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXTATJFJDMJMIY

Associated Genomic Regions

Region: rs2185152

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.513
Position:
76224010
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
28.103
Reference Allele:
C
-log10(P):
-398.463
MAF:
0.309
Beta (Num):
0.123
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.391
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic/Fatty Acid Metabolism

Denominator Metabolite Explanation:

Fatty Acid Beta-Oxidation3[1], 4[2]

Ratio Explanation:

This ratio likely reflects the balance between different detoxification pathways for medium-chain acyl-CoAs that accumulate due to reduced ACADM enzyme activity.5[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced ACADM activity impairs fatty acid beta-oxidation, leading to the accumulation and alternative conjugation of medium-chain fats.5[1] No associated phenotype was provided in the input data to establish a full causal chain.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data