nonanoylcarnitine (c9) to glutamine conjugate of c6h10o2 (2)*

Numerator Metabolite

Structure of nonanoylcarnitine (c9)
Metabolite Accession: GCST90200031
Name: nonanoylcarnitine (c9)
Hmdb Id: HMDB0013288
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPSPNFAQQQMFLK

Denominator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4949674

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.502
Position:
76213715
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-24.733
Reference Allele:
C
-log10(P):
-309.299
MAF:
0.302
Beta (Num):
-0.379
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.124
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Xenobiotic/dicarboxylic acid metabolism.

Ratio Explanation:

The ratio reflects ACADM activity; decreased function elevates the C9-carnitine numerator relative to a likely downstream or alternative pathway product of fatty acid metabolism.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced ACADM activity, indicated by an elevated ratio, is a known cause of Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD); however, no associated phenotype was provided.6[1], 7[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data