palmitoleoylcarnitine (c16:1)* to Hexanoylcarnitine

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of hexanoylcarnitine (c6)
Metabolite Accession: GCST90199668
Name: hexanoylcarnitine (c6)
Hmdb Id: HMDB0000756
Super Pathway: NA
Sub Pathway: NA
Inchikey: VVPRQWTYSNDTEA

Associated Genomic Regions

Region: rs61797339

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.418
Position:
76189946
SE (Ratio):
0.012
Effect Allele:
T
Z-score (Ratio):
33.667
Reference Allele:
G
-log10(P):
-570.491
MAF:
0.308
Beta (Num):
-0.012
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.430
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.147
Position:
160564476
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
9.417
Reference Allele:
C
-log10(P):
-46.823
MAF:
0.175
Beta (Num):
0.013
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.134
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.6[1], 7[2]

Ratio Explanation:

An elevated ratio of palmitoleoylcarnitine (C16:1) to hexanoylcarnitine (C6) may suggest inefficient beta-oxidation of longer-chain fatty acids, potentially due to reduced ACADM activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced ACADM function can lead to the accumulation of certain fatty acid intermediates, which is linked to disorders of lipoprotein metabolism and hypercholesterolemia.

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data