Infomap Cluster 97

Metabolite Network

mQTL individually significant in locus
Novel rQTL
Known rQTL

Aggregated Cluster Evidence

Significant GTEx eQTL Colocalization (P-alpha < 5e-5)

Tissue Gene P(alpha) Associated Metabolites
Heart Left Ventricle NFATC3 1.10e-05 acisogaadipoylcarnitine (c6-dc)hexanoylcarnitine (c6)n-acetyl-isoputreanineoctanoylcarnitine (c8)propionylcarnitine (c3)
Whole Blood SLC7A6 1.54e-05 acisogaadipoylcarnitine (c6-dc)hexanoylcarnitine (c6)n-acetyl-isoputreanineoctanoylcarnitine (c8)propionylcarnitine (c3)
Thyroid PLA2G15 3.73e-05 acisogaadipoylcarnitine (c6-dc)hexanoylcarnitine (c6)n-acetyl-isoputreanineoctanoylcarnitine (c8)propionylcarnitine (c3)

Genomic Context

Displaying 4 SNPs on Chr 6 for Cluster 97.

Novel rQTL (▲)
Known rQTL (▲)

Cluster Summary

85

Metabolite Ratios (rQTLs)

42

Total Unique Metabolites

8

Unnamed Metabolites

Ratios in Cluster 97

Ratio Name Novel in Cluster Driven By
2-oxoarginine* to adipoylcarnitine (c6-dc) No
2-oxoarginine* to methylsuccinoylcarnitine No
2-oxoarginine* to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc) No
2-oxoarginine* to succinylcarnitine (c4dc) No
2-oxoarginine* to x-23654 No
2-oxoarginine* to x-24801 No
3-hydroxyhexanoylcarnitine (1) to 3-hydroxyoleoylcarnitine Yes
3-hydroxyhexanoylcarnitine (1) to adipoylcarnitine (c6-dc) No
3-hydroxyhexanoylcarnitine (1) to glutamine conjugate of c6h10o2 (2)* Yes
3-hydroxyoleoylcarnitine to acetylcarnitine (c2) Yes
3-hydroxyoleoylcarnitine to Hexanoylcarnitine No
3-methylglutarylcarnitine (2) to butyrylcarnitine (c4) No
3-methylglutarylcarnitine (2) to phenylacetylcarnitine No
5-dodecenoylcarnitine (c12:1) to Hexanoylcarnitine No
5-methylthioadenosine (mta) to adipoylcarnitine (c6-dc) No
5-methylthioadenosine (mta) to dimethylarginine (sdma + adma) Yes
5-methylthioadenosine (mta) to glutarylcarnitine (c5-dc) Yes
5-methylthioadenosine (mta) to methylsuccinoylcarnitine No
5-methylthioadenosine (mta) to n-acetylputrescine Yes
5-methylthioadenosine (mta) to succinylcarnitine (c4dc) Yes
5-methylthioadenosine (mta) to x-23654 No
5-methylthioadenosine (mta) to x-24801 Yes
acisoga to 3-methylglutarylcarnitine (2) No
acisoga to adipoylcarnitine (c6-dc) No
acisoga to methylsuccinoylcarnitine No
acisoga to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc) No
acisoga to succinylcarnitine (c4dc) No
acisoga to x-23654 No
acisoga to x-24801 No
adipoylcarnitine (c6-dc) to acetylcarnitine (c2) No
adipoylcarnitine (c6-dc) to betaine No
adipoylcarnitine (c6-dc) to butyrylcarnitine (c4) No
adipoylcarnitine (c6-dc) to Hexanoylcarnitine No
adipoylcarnitine (c6-dc) to x-12112 No
adipoylcarnitine (c6-dc) to x-23641 No
argininate* to 3-methylglutarylcarnitine (2) No
argininate* to adipoylcarnitine (c6-dc) No
argininate* to methylsuccinoylcarnitine No
argininate* to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc) No
argininate* to succinylcarnitine (c4dc) No
argininate* to x-23654 No
argininate* to x-24801 No
butyrylcarnitine (c4) to x-23654 No
butyrylcarnitine (c4) to x-24801 No
cis 3,4-methyleneheptanoate to adipoylcarnitine (c6-dc) No
cis 3,4-methyleneheptanoate to methylsuccinoylcarnitine No
cis 3,4-methyleneheptanoate to n-acetyl-isoputreanine No
cis 3,4-methyleneheptanoate to succinylcarnitine (c4dc) No
cis 3,4-methyleneheptanoate to x-11478 No
cis 3,4-methyleneheptanoate to x-18921 No
cis 3,4-methyleneheptanoate to x-23654 No
cis 3,4-methyleneheptanoate to x-24801 No
cis-3,4-methyleneheptanoylcarnitine to 3-methylglutarylcarnitine (2) No
cis-3,4-methyleneheptanoylcarnitine to adipoylcarnitine (c6-dc) No
cis-3,4-methyleneheptanoylcarnitine to methylsuccinoylcarnitine No
cis-3,4-methyleneheptanoylcarnitine to n-acetyl-isoputreanine No
cis-3,4-methyleneheptanoylcarnitine to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc) No
cis-3,4-methyleneheptanoylcarnitine to succinylcarnitine (c4dc) No
cis-3,4-methyleneheptanoylcarnitine to x-11478 No
cis-3,4-methyleneheptanoylcarnitine to x-15486 No
cis-3,4-methyleneheptanoylcarnitine to x-18921 No
cis-3,4-methyleneheptanoylcarnitine to x-23654 No
cis-3,4-methyleneheptanoylcarnitine to x-23680 No
cis-3,4-methyleneheptanoylcarnitine to x-24801 No
glutarylcarnitine (c5-dc) to Hexanoylcarnitine No
glutarylcarnitine (c5-dc) to n-acetylarginine Yes
isobutyrylcarnitine (c4) to 3-methylglutarylcarnitine (2) No Denominator, Numerator
isobutyrylcarnitine (c4) to methylsuccinoylcarnitine No
isobutyrylcarnitine (c4) to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc) No
levulinoylcarnitine to 3-methylglutarylcarnitine (2) No
levulinoylcarnitine to adipoylcarnitine (c6-dc) No
levulinoylcarnitine to methylsuccinoylcarnitine No
levulinoylcarnitine to n-acetyl-isoputreanine No
levulinoylcarnitine to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc) No
levulinoylcarnitine to succinylcarnitine (c4dc) No
levulinoylcarnitine to x-23654 No
levulinoylcarnitine to x-24801 No
methylsuccinoylcarnitine to betaine No
methylsuccinoylcarnitine to butyrylcarnitine (c4) No
methylsuccinoylcarnitine to Hexanoylcarnitine No
methylsuccinoylcarnitine to n-acetylarginine No
methylsuccinoylcarnitine to x-23641 No
myristoleoylcarnitine (c14:1)* to Hexanoylcarnitine No
n-acetyl-isoputreanine to 2-oxoarginine* No
n-acetyl-isoputreanine to 5-methylthioadenosine (mta) No
n-acetyl-isoputreanine to acisoga No
n-acetyl-isoputreanine to argininate* No
n-acetyl-isoputreanine to betaine No
n-acetyl-isoputreanine to butyrylcarnitine (c4) No
n-acetyl-isoputreanine to Hexanoylcarnitine No
n-acetyl-isoputreanine to phenylacetylcarnitine No
n-acetyl-isoputreanine to propionylcarnitine (c3) No
n-acetyl-isoputreanine to x-23641 No
n-acetylarginine to x-24801 Yes
n6,n6-dimethyllysine to x-12112 Yes
n6-methyllysine to x-12112 Yes
octanoylcarnitine (c8) to Hexanoylcarnitine No
palmitoleoylcarnitine (c16:1)* to Hexanoylcarnitine No
phenylacetylcarnitine to adipoylcarnitine (c6-dc) No
phenylacetylcarnitine to methylsuccinoylcarnitine No
phenylacetylcarnitine to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc) No
phenylacetylcarnitine to succinylcarnitine (c4dc) No
phenylacetylcarnitine to x-23654 No
phenylacetylcarnitine to x-24801 No
pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc) to betaine No
pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc) to butyrylcarnitine (c4) No
pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc) to Hexanoylcarnitine No
propionylcarnitine (c3) to adipoylcarnitine (c6-dc) No
propionylcarnitine (c3) to glutarylcarnitine (c5-dc) No
propionylcarnitine (c3) to methylsuccinoylcarnitine No
propionylcarnitine (c3) to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc) No
propionylcarnitine (c3) to succinylcarnitine (c4dc) No
propionylcarnitine (c3) to x-23654 No
propionylcarnitine (c3) to x-24801 No
succinylcarnitine (c4dc) to 4-guanidinobutanoate Yes
succinylcarnitine (c4dc) to betaine No
succinylcarnitine (c4dc) to butyrylcarnitine (c4) No
succinylcarnitine (c4dc) to n-acetylarginine Yes
succinylcarnitine (c4dc) to x-12112 Yes
succinylcarnitine (c4dc) to x-23641 Yes
x-12112 to x-24801 Yes
x-23654 to Hexanoylcarnitine No
x-23654 to x-23641 No
x-24801 to Hexanoylcarnitine No
x-24801 to x-23641 Yes