cis-3,4-methyleneheptanoylcarnitine to succinylcarnitine (c4dc)

Numerator Metabolite

Metabolite Accession: GCST90200266
Name: cis-3,4-methyleneheptanoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of succinylcarnitine (c4-dc)
Metabolite Accession: GCST90199848
Name: succinylcarnitine (c4-dc)
Hmdb Id: HMDB0061717
Super Pathway: NA
Sub Pathway: NA
Inchikey: HAEVNYBCYZZDFL

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.374
Position:
160564476
SE (Ratio):
0.026
Effect Allele:
G
Z-score (Ratio):
-14.147
Reference Allele:
C
-log10(P):
-102.947
MAF:
0.175
Beta (Num):
-0.245
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.129
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Branched-chain amino acid catabolism, TCA cycle.6[1], 7[2], 8[3]

Ratio Explanation:

Increased ratio may reflect altered mitochondrial function, where decreased SOD2 activity impacts pathways producing succinylcarnitine, alongside changes in fatty acid metabolism or gut microbe activity influencing the numerator.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Impaired SOD2 function contributes to oxidative stress, a known factor in atherosclerosis. This altered redox state may influence both cis-3,4-methyleneheptanoylcarnitine (a gut microbe-derived xenometabolite) and succinylcarnitine levels, linking mitochondrial health to cardiovascular phenotypes and lipoprotein metabolism.1[1], 2[2], 3[3], 5[4], 9[5], 10[6]

Phenotype Driver:

Gene-centric:SOD2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data