adipoylcarnitine (c6-dc) to betaine

Numerator Metabolite

Structure of adipoylcarnitine (c6-dc)
Metabolite Accession: GCST90200018
Name: adipoylcarnitine (c6-dc)
Hmdb Id: HMDB0061677
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSVHAXJKBCWVDA

Denominator Metabolite

Structure of betaine
Metabolite Accession: GCST90200425
Name: betaine
Hmdb Id: HMDB0000043
Super Pathway: NA
Sub Pathway: NA
Inchikey: KWIUHFFTVRNATP

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.313
Position:
160564476
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
11.593
Reference Allele:
C
-log10(P):
-69.883
MAF:
0.175
Beta (Num):
0.161
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.152
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation

Denominator Metabolite Explanation:

Choline and methyl-group metabolism

Ratio Explanation:

A high ratio of adipoylcarnitine to betaine may signify altered fatty acid oxidation relative to methyl-donor pathways, potentially influenced by SLC22A1 transport activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A1 function is associated with altered lipid profiles, including higher LDL cholesterol.5[1], 6[2], 7[3] An elevated adipoylcarnitine/betaine ratio may reflect this dysregulation, contributing to an increased risk for atherosclerosis and related ischemic heart disease by promoting atherogenic lipid environments.

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data