levulinoylcarnitine to n-acetyl-isoputreanine

Numerator Metabolite

Metabolite Accession: GCST90200247
Name: levulinoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of n-acetyl-isoputreanine
Metabolite Accession: GCST90200195
Name: n-acetyl-isoputreanine
Hmdb Id: HMDB0094713
Super Pathway: NA
Sub Pathway: NA
Inchikey: YGIAGXACEXFIDU

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.306
Position:
160564476
SE (Ratio):
0.029
Effect Allele:
G
Z-score (Ratio):
-10.457
Reference Allele:
C
-log10(P):
-57.261
MAF:
0.173
Beta (Num):
-0.167
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.138
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism

Denominator Metabolite Explanation:

Polyamine metabolism

Ratio Explanation:

The ratio may reflect the balance between xenobiotic exposure and polyamine catabolism, potentially influenced by SLC22A1's role in transporting organic cations.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A1 function could impact the transport of levulinoylcarnitine or other organic cations, indirectly affecting lipid metabolism. The link to n-acetyl-isoputreanine and polyamine metabolism is less clear but may involve downstream effects on cellular processes that influence lipoprotein levels.

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data