cis 3,4-methyleneheptanoate to adipoylcarnitine (c6-dc)

Numerator Metabolite

Metabolite Accession: GCST90200248
Name: cis-3,4-methyleneheptanoate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of adipoylcarnitine (c6-dc)
Metabolite Accession: GCST90200018
Name: adipoylcarnitine (c6-dc)
Hmdb Id: HMDB0061677
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSVHAXJKBCWVDA

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.301
Position:
160564476
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
-12.295
Reference Allele:
C
-log10(P):
-78.324
MAF:
0.175
Beta (Num):
-0.140
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.161
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism

Denominator Metabolite Explanation:

Fatty acid omega-oxidation

Ratio Explanation:

The ratio of cis 3,4-methyleneheptanoate to adipoylcarnitine may reflect mitochondrial stress, as SOD2 protects mitochondria where adipoylcarnitine is metabolized.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

SOD2 variation can impair mitochondrial antioxidant defense, increasing oxidative stress.4[1], 5[2], 6[3] This disrupts lipid metabolism, reflected in the metabolite ratio, and contributes to the development of dyslipidemia and atherosclerosis, the associated phenotypes.7[4], 8[5]

Phenotype Driver:

Gene-centric:SOD2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data