3-hydroxyoleoylcarnitine to acetylcarnitine (c2)

Numerator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.157
Position:
160564476
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
9.083
Reference Allele:
C
-log10(P):
-43.696
MAF:
0.176
Beta (Num):
0.070
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.087
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid β-oxidation. 4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, acetyl-CoA buffer. 6[1], 7[2]

Ratio Explanation:

An elevated ratio of 3-hydroxyoleoylcarnitine to acetylcarnitine could indicate altered fatty acid oxidation, potentially influenced by SLC22A1-mediated transport of these carnitine species. 1[1], 2[2], 3[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A1 function may lead to altered acylcarnitine profiles, which are associated with disturbances in lipoprotein metabolism and hypercholesterolemia. 8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data