n-acetyl-isoputreanine to argininate*

Numerator Metabolite

Structure of n-acetyl-isoputreanine
Metabolite Accession: GCST90200195
Name: n-acetyl-isoputreanine
Hmdb Id: HMDB0094713
Super Pathway: NA
Sub Pathway: NA
Inchikey: YGIAGXACEXFIDU

Denominator Metabolite

Structure of argininate*
Metabolite Accession: GCST90199900
Name: argininate*
Hmdb Id: HMDB0003148
Super Pathway: NA
Sub Pathway: NA
Inchikey: BMFMQGXDDJALKQ

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.360
Position:
160564476
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
13.178
Reference Allele:
C
-log10(P):
-89.641
MAF:
0.175
Beta (Num):
0.138
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.221
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Polyamine metabolism.11[1], 12[2], 13[3], 14[4], 15[5]

Denominator Metabolite Explanation:

Arginine metabolism.16[1], 17[2], 18[3], 19[4], 20[5]

Ratio Explanation:

The ratio may reflect the balance between polyamine catabolism (n-acetyl-isoputreanine) and arginine availability, potentially modulated by the transporter activity of SLC22A1.1[1], 6[2], 11[3], 13[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced function of the organic cation transporter SLC22A1 is associated with higher total and LDL cholesterol.3[1], 4[2], 8[3], 21[4] SLC22A1 transports compounds that regulate lipid metabolism, suggesting that its altered function affects circulating lipid levels, leading to hypercholesterolemia and related lipoprotein metabolism disorders.3[5], 4[6], 6[7]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data