phenylacetylcarnitine to methylsuccinoylcarnitine

Numerator Metabolite

Metabolite Accession: GCST90199993
Name: phenylacetylcarnitine
Hmdb Id: HMDB0341372
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200089
Name: methylsuccinoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.325
Position:
160564476
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
-11.846
Reference Allele:
C
-log10(P):
-72.867
MAF:
0.175
Beta (Num):
-0.165
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.160
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Phenylalanine metabolism, gut microbial metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Fatty acid metabolism, amino acid metabolism.9[1], 10[2], 11[3], 12[4], 13[5]

Ratio Explanation:

The ratio may reflect altered hepatic transport of acylcarnitines by SLC22A1, impacting both fatty acid and amino acid metabolism.14[1], 15[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A1 function may alter the transport of both phenylacetylcarnitine and methylsuccinoylcarnitine, contributing to dyslipidemia and hypercholesterolemia by affecting hepatic lipid and energy balance.3[1], 4[2], 5[3], 16[4]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data