n-acetyl-isoputreanine to phenylacetylcarnitine

Numerator Metabolite

Structure of n-acetyl-isoputreanine
Metabolite Accession: GCST90200195
Name: n-acetyl-isoputreanine
Hmdb Id: HMDB0094713
Super Pathway: NA
Sub Pathway: NA
Inchikey: YGIAGXACEXFIDU

Denominator Metabolite

Metabolite Accession: GCST90199993
Name: phenylacetylcarnitine
Hmdb Id: HMDB0341372
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.303
Position:
160564476
SE (Ratio):
0.028
Effect Allele:
G
Z-score (Ratio):
10.923
Reference Allele:
C
-log10(P):
-62.276
MAF:
0.175
Beta (Num):
0.138
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.165
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Polyamine metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid and xenobiotic metabolism.6[1], 7[2]

Ratio Explanation:

This ratio may reflect competitive transport of n-acetyl-isoputreanine and phenylacetylcarnitine by SLC22A1, an organic cation transporter.1[1], 2[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A1 function likely impacts the transport of both metabolites and influences hepatic lipid metabolism, leading to hypercholesterolemia and lipoprotein disorders.8[1], 9[2], 10[3] Reduced SLC22A1 function is associated with higher total and LDL cholesterol.8[4], 9[5]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data