succinylcarnitine (c4dc) to butyrylcarnitine (c4)

Numerator Metabolite

Structure of succinylcarnitine (c4-dc)
Metabolite Accession: GCST90199848
Name: succinylcarnitine (c4-dc)
Hmdb Id: HMDB0061717
Super Pathway: NA
Sub Pathway: NA
Inchikey: HAEVNYBCYZZDFL

Denominator Metabolite

Structure of butyrylcarnitine (c4)
Metabolite Accession: GCST90200673
Name: butyrylcarnitine (c4)
Hmdb Id: HMDB0002013
Super Pathway: NA
Sub Pathway: NA
Inchikey: QWYFHHGCZUCMBN

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.329
Position:
160564476
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
12.018
Reference Allele:
C
-log10(P):
-74.932
MAF:
0.176
Beta (Num):
0.129
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.200
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation, amino acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid β-oxidation. 6[1]

Ratio Explanation:

The ratio of succinylcarnitine to butyrylcarnitine may reflect altered fatty acid and amino acid metabolism, potentially influenced by SLC22A1-mediated transport of carnitine precursors.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced function of the organic cation transporter SLC22A1 may alter hepatic carnitine uptake, affecting fatty acid and amino acid metabolism, which is reflected in the succinylcarnitine to butyrylcarnitine ratio and is associated with an increased risk for dyslipidemia and coronary artery disease. 7[1], 8[2], 9[3], 10[4]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data