levulinoylcarnitine to methylsuccinoylcarnitine

Numerator Metabolite

Metabolite Accession: GCST90200247
Name: levulinoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200089
Name: methylsuccinoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.327
Position:
160564476
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
-11.992
Reference Allele:
C
-log10(P):
-74.619
MAF:
0.173
Beta (Num):
-0.167
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.160
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotics, Fatty Acid Metabolism.3[1], 4[2], 5[3], 6[4]

Denominator Metabolite Explanation:

Fatty Acid Metabolism, Amino Acid Metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect altered transport or metabolism of these acylcarnitines, potentially due to SLC22A1's role in their transport across cell membranes.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced function of the organic cation transporter SLC22A1 may alter the transport of levulinoylcarnitine and methylsuccinoylcarnitine, impacting lipid metabolism.1[1], 10[2], 11[3] This is linked to disorders of lipoprotein metabolism and coronary atherosclerosis, potentially through downstream effects on cholesterol and other lipids.10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data