5-methylthioadenosine (mta) to adipoylcarnitine (c6-dc)

Numerator Metabolite

Structure of 5-methylthioadenosine (mta)
Metabolite Accession: GCST90200359
Name: 5-methylthioadenosine (mta)
Hmdb Id: HMDB0001173
Super Pathway: NA
Sub Pathway: NA
Inchikey: WUUGFSXJNOTRMR

Denominator Metabolite

Structure of adipoylcarnitine (c6-dc)
Metabolite Accession: GCST90200018
Name: adipoylcarnitine (c6-dc)
Hmdb Id: HMDB0061677
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSVHAXJKBCWVDA

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.275
Position:
160564476
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
-11.428
Reference Allele:
C
-log10(P):
-67.964
MAF:
0.176
Beta (Num):
-0.115
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.161
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Methionine salvage, polyamine biosynthesis.4[1], 5[2], 6[3], 7[4], 8[5]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.

Ratio Explanation:

The ratio reflects the transport activity of SLC22A1, a transporter for organic cations like MTA and acylcarnitines, thus influencing their relative concentrations.3[1], 9[2], 10[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the SLC22A1 transporter alters its function, impacting the mta/c6-dc ratio. This dysregulation is strongly associated with disorders of lipoprotein metabolism and hypercholesterolemia, indicating SLC22A1's crucial role in maintaining lipid homeostasis.11[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data