adipoylcarnitine (c6-dc) to acetylcarnitine (c2)

Numerator Metabolite

Structure of adipoylcarnitine (c6-dc)
Metabolite Accession: GCST90200018
Name: adipoylcarnitine (c6-dc)
Hmdb Id: HMDB0061677
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSVHAXJKBCWVDA

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.248
Position:
160564476
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
10.907
Reference Allele:
C
-log10(P):
-62.108
MAF:
0.175
Beta (Num):
0.161
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.087
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation, peroxisomal metabolism.9[1], 10[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, amino acid metabolism.11[1], 12[2], 13[3], 14[4]

Ratio Explanation:

An elevated ratio may indicate altered SLC22A1-mediated transport of these carnitines, potentially reflecting changes in fatty acid and amino acid metabolism.2[1], 4[2], 11[3], 12[4], 13[5], 14[6]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered SLC22A1 function may influence circulating levels of adipoylcarnitine and acetylcarnitine, which are associated with lipoprotein metabolism disorders and hypercholesterolemia.15[1], 16[2], 17[3], 18[4], 19[5], 20[6], 21[7] SOD2's role in mitigating oxidative stress could also be relevant as hypercholesterolemia is linked to increased oxidative stress.22[8], 23[9], 24[10], 25[11], 26[12], 27[13], 28[14], 29[15], 30[16], 31[17], 32[18], 33[19], 34[20], 35[21], 36[22]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data