argininate* to adipoylcarnitine (c6-dc)

Numerator Metabolite

Structure of argininate*
Metabolite Accession: GCST90199900
Name: argininate*
Hmdb Id: HMDB0003148
Super Pathway: NA
Sub Pathway: NA
Inchikey: BMFMQGXDDJALKQ

Denominator Metabolite

Structure of adipoylcarnitine (c6-dc)
Metabolite Accession: GCST90200018
Name: adipoylcarnitine (c6-dc)
Hmdb Id: HMDB0061677
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSVHAXJKBCWVDA

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.382
Position:
160564476
SE (Ratio):
0.030
Effect Allele:
G
Z-score (Ratio):
-12.916
Reference Allele:
C
-log10(P):
-86.196
MAF:
0.175
Beta (Num):
-0.221
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.161
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Urea cycle, Nitric oxide synthesis3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation5[1]

Ratio Explanation:

The ratio likely reflects SLC22A1 transport activity, as it mediates efflux of both argininate and adipoylcarnitine, which are both organic cations.2[1], 6[2], 7[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SLC22A1 alters its transport of argininate and adipoylcarnitine, impacting carnitine-dependent fatty acid oxidation and hepatic lipid metabolism, which contributes to dyslipidemia and elevated cholesterol levels.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data