succinylcarnitine (c4dc) to n-acetylarginine

Numerator Metabolite

Structure of succinylcarnitine (c4-dc)
Metabolite Accession: GCST90199848
Name: succinylcarnitine (c4-dc)
Hmdb Id: HMDB0061717
Super Pathway: NA
Sub Pathway: NA
Inchikey: HAEVNYBCYZZDFL

Denominator Metabolite

Structure of n-acetylarginine
Metabolite Accession: GCST90200679
Name: n-acetylarginine
Hmdb Id: HMDB0004620
Super Pathway: NA
Sub Pathway: NA
Inchikey: SNEIUMQYRCDYCH

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
0.238
Position:
160564476
SE (Ratio):
0.026
Effect Allele:
G
Z-score (Ratio):
9.095
Reference Allele:
C
-log10(P):
-43.802
MAF:
0.176
Beta (Num):
0.129
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.109
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation, amino acid metabolism.5[1]

Denominator Metabolite Explanation:

Arginine metabolism, urea cycle.6[1], 7[2]

Ratio Explanation:

The ratio may reflect altered transport activity by SLC22A1 in the liver and kidney, impacting the balance of these two organic cations.3[1], 8[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A1 function can alter hepatic and renal clearance of metabolites, including lipids, contributing to dyslipidemia and chronic kidney disease, with the ratio reflecting this dysfunction.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data