cis 3,4-methyleneheptanoate to methylsuccinoylcarnitine

Numerator Metabolite

Metabolite Accession: GCST90200248
Name: cis-3,4-methyleneheptanoate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200089
Name: methylsuccinoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs11753995

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.316
Position:
160575366
SE (Ratio):
0.031
Effect Allele:
A
Z-score (Ratio):
-10.102
Reference Allele:
G
-log10(P):
-53.575
MAF:
0.164
Beta (Num):
-0.148
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.168
SE (Den):
0.021
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Branched-chain amino acid catabolism.7[1], 8[2]

Ratio Explanation:

This ratio may reflect mitochondrial metabolic balance. Altered SOD2 function can impact mitochondrial pathways, including fatty acid and amino acid metabolism, affecting this ratio.3[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SOD2 function increases mitochondrial oxidative stress, a key factor in cardiovascular diseases.2[1], 3[2] This metabolic dysregulation, indicated by the altered metabolite ratio, is linked to atherosclerosis and hypercholesterolemia.

Phenotype Driver:

Gene-centric:SOD2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data