2-oxoarginine* to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)

Numerator Metabolite

Structure of 2-oxoarginine*
Metabolite Accession: GCST90199903
Name: 2-oxoarginine*
Hmdb Id: HMDB0004225
Super Pathway: NA
Sub Pathway: NA
Inchikey: ARBHXJXXVVHMET

Denominator Metabolite

Structure of pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Metabolite Accession: GCST90200101
Name: pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Hmdb Id: HMDB0013328
Super Pathway: NA
Sub Pathway: NA
Inchikey: NTBUXPPQHCFLOM

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.356
Position:
160564476
SE (Ratio):
0.029
Effect Allele:
G
Z-score (Ratio):
-12.144
Reference Allele:
C
-log10(P):
-76.464
MAF:
0.175
Beta (Num):
-0.149
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.207
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Arginine metabolism, Urea cycle.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid dicarboxylate metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect altered transport of acylcarnitines by SLC22A1, impacting both fatty acid and amino acid metabolism, but a direct link is unclear.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The SLC22A1 transporter, by influencing carnitine and acylcarnitine levels, may affect fatty acid metabolism which is linked to lipoprotein disorders and hypercholesterolemia.2[1], 3[2], 10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data