levulinoylcarnitine to 3-methylglutarylcarnitine (2)

Numerator Metabolite

Metabolite Accession: GCST90200247
Name: levulinoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-methylglutarylcarnitine (2)
Metabolite Accession: GCST90199971
Name: 3-methylglutarylcarnitine (2)
Hmdb Id: HMDB0000552
Super Pathway: NA
Sub Pathway: NA
Inchikey: HFCPFJNSBPQJDP

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.325
Position:
160564476
SE (Ratio):
0.028
Effect Allele:
G
Z-score (Ratio):
-11.664
Reference Allele:
C
-log10(P):
-70.711
MAF:
0.173
Beta (Num):
-0.167
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.158
SE (Den):
0.019
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, food component.2[1], 3[2]

Denominator Metabolite Explanation:

Leucine catabolism.4[1], 5[2]

Ratio Explanation:

The ratio may reflect a shift in mitochondrial state, possibly increased xenobiotic metabolism or heme turnover relative to amino acid catabolism, potentially driven by oxidative stress.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SOD2 function likely increases mitochondrial oxidative stress, a key factor in the pathogenesis of dyslipidemia and ischaemic heart disease.6[1], 7[2], 8[3], 9[4], 10[5] The acylcarnitine ratio may act as a biomarker for this underlying stress, which is linked to the cardiometabolic phenotypes.11[6]

Phenotype Driver:

Gene-centric:SOD2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data