3-hydroxyoleoylcarnitine to Hexanoylcarnitine

Numerator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Denominator Metabolite

Structure of hexanoylcarnitine (c6)
Metabolite Accession: GCST90199668
Name: hexanoylcarnitine (c6)
Hmdb Id: HMDB0000756
Super Pathway: NA
Sub Pathway: NA
Inchikey: VVPRQWTYSNDTEA

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.204
Position:
160564476
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
10.489
Reference Allele:
C
-log10(P):
-57.591
MAF:
0.176
Beta (Num):
0.070
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.134
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid β-oxidation

Denominator Metabolite Explanation:

Fatty acid metabolism, Lipid transport

Ratio Explanation:

The ratio of 3-hydroxyoleoylcarnitine to hexanoylcarnitine may reflect alterations in fatty acid oxidation and transport, potentially influenced by SLC22A1 activity. 1[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The link between the ratio and phenotype is likely driven by altered lipid metabolism. SLC22A1, a transporter of acylcarnitines, may influence circulating lipid levels. 1[1], 2[2]This aligns with the observed association with disorders of lipoprotein metabolism and hypercholesterolemia, as well as altered levels of cholesterol and related biomarkers.

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data