cis 3,4-methyleneheptanoate to n-acetyl-isoputreanine

Numerator Metabolite

Metabolite Accession: GCST90200248
Name: cis-3,4-methyleneheptanoate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of n-acetyl-isoputreanine
Metabolite Accession: GCST90200195
Name: n-acetyl-isoputreanine
Hmdb Id: HMDB0094713
Super Pathway: NA
Sub Pathway: NA
Inchikey: YGIAGXACEXFIDU

Associated Genomic Regions

Region: rs11753995

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.288
Position:
160575366
SE (Ratio):
0.029
Effect Allele:
A
Z-score (Ratio):
-10.092
Reference Allele:
G
-log10(P):
-53.476
MAF:
0.164
Beta (Num):
-0.148
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.140
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism

Denominator Metabolite Explanation:

Polyamine metabolism

Ratio Explanation:

An elevated ratio may suggest a shift from polyamine catabolism to fatty acid synthesis, potentially influenced by SOD2-mediated oxidative stress, though the direct link is unclear.4[1], 5[2], 6[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

SOD2's role in mitigating oxidative stress could influence lipid peroxidation and overall lipid metabolism.7[1], 3[2] Altered SOD2 function may contribute to the dyslipidemia phenotype, with the metabolite ratio reflecting a downstream metabolic consequence of this oxidative stress.

Phenotype Driver:

Gene-centric:SOD2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data