argininate* to 3-methylglutarylcarnitine (2)

Numerator Metabolite

Structure of argininate*
Metabolite Accession: GCST90199900
Name: argininate*
Hmdb Id: HMDB0003148
Super Pathway: NA
Sub Pathway: NA
Inchikey: BMFMQGXDDJALKQ

Denominator Metabolite

Structure of 3-methylglutarylcarnitine (2)
Metabolite Accession: GCST90199971
Name: 3-methylglutarylcarnitine (2)
Hmdb Id: HMDB0000552
Super Pathway: NA
Sub Pathway: NA
Inchikey: HFCPFJNSBPQJDP

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.380
Position:
160564476
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
-14.207
Reference Allele:
C
-log10(P):
-103.800
MAF:
0.175
Beta (Num):
-0.221
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.158
SE (Den):
0.019
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Arginine metabolism, urea cycle.6[1], 7[2], 8[3], 9[4]

Denominator Metabolite Explanation:

Leucine catabolism, fatty acid metabolism.10[1], 11[2]

Ratio Explanation:

The ratio reflects the balance between arginine derivative availability and leucine catabolism byproduct transport, potentially influenced by competitive transport via SLC22A1.2[1], 12[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the SLC22A1 transporter likely alters the transport of argininate and 3-methylglutarylcarnitine.2[1], 12[2] This altered transport is associated with changes in lipid profiles, including LDL cholesterol, and an increased risk for ischemic heart disease and atherosclerosis.3[3], 4[4], 5[5], 13[6]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data