n-acetyl-isoputreanine to acisoga

Numerator Metabolite

Structure of n-acetyl-isoputreanine
Metabolite Accession: GCST90200195
Name: n-acetyl-isoputreanine
Hmdb Id: HMDB0094713
Super Pathway: NA
Sub Pathway: NA
Inchikey: YGIAGXACEXFIDU

Denominator Metabolite

Structure of acisoga
Metabolite Accession: GCST90199962
Name: acisoga
Hmdb Id: HMDB0061384
Super Pathway: NA
Sub Pathway: NA
Inchikey: OAUYENAPBFTAQT

Associated Genomic Regions

Region: rs662138

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.341
Position:
160564476
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
16.892
Reference Allele:
C
-log10(P):
-145.721
MAF:
0.175
Beta (Num):
0.138
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.202
SE (Den):
0.021
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

Region: rs6464114

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-0.331
Position:
150539253
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-21.579
Reference Allele:
G
-log10(P):
-236.135
MAF:
0.471
Beta (Num):
-0.245
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.086
SE (Den):
0.016
No CNV overlap
rQTL cluster:
87
Reaction Distance:
NA
Closest Genes:
AOC1 TMEM176A TMEM176B GIMAP5 KCNH2

LLM Analysis

Numerator Metabolite Explanation:

Polyamine catabolism3[1], 4[2], 5[3], 6[4], 7[5]

Denominator Metabolite Explanation:

Polyamine catabolism8[1], 9[2], 10[3], 11[4]

Ratio Explanation:

This ratio may reflect activity in the polyamine catabolism pathway where AOC1, a copper-dependent amine oxidase, is a key enzyme.1[1], 10[2] Acisoga is a downstream product of N1-acetylspermidine oxidation.8[3], 9[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered AOC1 gene function likely modifies polyamine catabolism. This metabolic shift, reflected by the ratio, is associated with disorders of lipoprotein metabolism and atherosclerosis, potentially through inflammatory or oxidative stress pathways linked to polyamine breakdown products.12[1], 13[2], 14[3], 15[4], 16[5]

Phenotype Driver:

Gene-centric:AOC1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data