5-methylthioadenosine (mta) to succinylcarnitine (c4dc)

Numerator Metabolite

Structure of 5-methylthioadenosine (mta)
Metabolite Accession: GCST90200359
Name: 5-methylthioadenosine (mta)
Hmdb Id: HMDB0001173
Super Pathway: NA
Sub Pathway: NA
Inchikey: WUUGFSXJNOTRMR

Denominator Metabolite

Structure of succinylcarnitine (c4-dc)
Metabolite Accession: GCST90199848
Name: succinylcarnitine (c4-dc)
Hmdb Id: HMDB0061717
Super Pathway: NA
Sub Pathway: NA
Inchikey: HAEVNYBCYZZDFL

Associated Genomic Regions

Region: rs662138

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.243
Position:
160564476
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-10.961
Reference Allele:
C
-log10(P):
-62.696
MAF:
0.176
Beta (Num):
-0.115
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.129
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Methionine salvage, polyamine biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, amino acid metabolism.7[1]

Ratio Explanation:

The ratio may reflect competitive transport by SLC22A1, which can transport both acylcarnitines and potentially MTA, affecting their relative concentrations.8[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the SLC22A1 transporter gene are associated with altered mta to c4dc ratios and concurrently with disorders of lipoprotein metabolism.10[1], 11[2] This suggests that SLC22A1's role in transporting these or related molecules influences lipid homeostasis, leading to phenotypes like hypercholesterolemia.12[3]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data