succinylcarnitine (c4dc) to 4-guanidinobutanoate

Numerator Metabolite

Structure of succinylcarnitine (c4-dc)
Metabolite Accession: GCST90199848
Name: succinylcarnitine (c4-dc)
Hmdb Id: HMDB0061717
Super Pathway: NA
Sub Pathway: NA
Inchikey: HAEVNYBCYZZDFL

Denominator Metabolite

Structure of 4-guanidinobutanoate
Metabolite Accession: GCST90199640
Name: 4-guanidinobutanoate
Hmdb Id: HMDB0003464
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUHVEAJXIMEOSA

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.215
Position:
160564476
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
8.889
Reference Allele:
C
-log10(P):
-41.928
MAF:
0.176
Beta (Num):
0.129
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.086
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation, amino acid catabolism, TCA cycle.8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Arginine and proline metabolism, urea cycle.11[1], 12[2], 13[3]

Ratio Explanation:

Succinylcarnitine is an intermediate in several mitochondrial metabolic pathways, while 4-guanidinobutanoate is involved in arginine metabolism; their ratio may reflect shifts in energy substrate utilization.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The LPA pQTL suggests a primary link between lipoprotein(a) levels and the observed cardiovascular phenotypes.1[1], 2[2], 3[3] Elevated Lp(a) is a known causal factor for atherosclerosis and related heart diseases.1[4], 2[5], 14[6] The metabolite ratio alteration might be a downstream secondary effect of LPA-driven pathology or related metabolic dysregulation.

Phenotype Driver:

Gene-centric:LPA

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data