cis 3,4-methyleneheptanoate to succinylcarnitine (c4dc)

Numerator Metabolite

Metabolite Accession: GCST90200248
Name: cis-3,4-methyleneheptanoate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of succinylcarnitine (c4-dc)
Metabolite Accession: GCST90199848
Name: succinylcarnitine (c4-dc)
Hmdb Id: HMDB0061717
Super Pathway: NA
Sub Pathway: NA
Inchikey: HAEVNYBCYZZDFL

Associated Genomic Regions

Region: rs11753995

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.275
Position:
160575366
SE (Ratio):
0.029
Effect Allele:
A
Z-score (Ratio):
-9.634
Reference Allele:
G
-log10(P):
-48.906
MAF:
0.164
Beta (Num):
-0.148
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.127
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis

Denominator Metabolite Explanation:

Fatty acid oxidation, amino acid metabolism.6[1], 7[2]

Ratio Explanation:

A higher ratio may indicate altered transport or metabolism of succinylcarnitine relative to cis-3,4-methyleneheptanoate, potentially mediated by SLC22A1 affecting acylcarnitine efflux from the liver.3[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered SLC22A1 function may modify circulating acylcarnitine levels, including succinylcarnitine.3[1], 5[2] Dysregulation of acylcarnitine and fatty acid metabolism is linked to hypercholesterolemia and ischemic heart disease, consistent with the observed phenotypes.8[3], 9[4], 10[5], 11[6]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data