5-methylthioadenosine (mta) to dimethylarginine (sdma + adma)

Numerator Metabolite

Structure of 5-methylthioadenosine (mta)
Metabolite Accession: GCST90200359
Name: 5-methylthioadenosine (mta)
Hmdb Id: HMDB0001173
Super Pathway: NA
Sub Pathway: NA
Inchikey: WUUGFSXJNOTRMR

Denominator Metabolite

Structure of dimethylarginine (sdma + adma)
Metabolite Accession: GCST90199832
Name: dimethylarginine (sdma + adma)
Hmdb Id: HMDB0003334,HMDB0001539
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDGMGEXADBMOMJ

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.192
Position:
160564476
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-8.680
Reference Allele:
C
-log10(P):
-40.074
MAF:
0.176
Beta (Num):
-0.115
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.078
SE (Den):
0.019
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Methionine salvage, polyamine biosynthesis.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Protein arginine methylation byproduct.6[1], 7[2]

Ratio Explanation:

The ratio reflects the balance between methionine salvage/polyamine synthesis (MTA) and protein turnover/arginine methylation (dimethylarginines), potentially modulated by shared SLC22A1-mediated transport.1[1], 8[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A1 function is linked to higher cholesterol.9[1], 10[2] SLC22A1 mediates hepatic thiamine uptake, and its deficiency alters lipid metabolism, phenocopying the associated hypercholesterolemia. The ratio is likely a biomarker of this altered metabolic state rather than a direct cause.10[3]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data