methylsuccinoylcarnitine to Hexanoylcarnitine

Numerator Metabolite

Metabolite Accession: GCST90200089
Name: methylsuccinoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of hexanoylcarnitine (c6)
Metabolite Accession: GCST90199668
Name: hexanoylcarnitine (c6)
Hmdb Id: HMDB0000756
Super Pathway: NA
Sub Pathway: NA
Inchikey: VVPRQWTYSNDTEA

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.294
Position:
160564476
SE (Ratio):
0.028
Effect Allele:
G
Z-score (Ratio):
10.656
Reference Allele:
C
-log10(P):
-59.381
MAF:
0.177
Beta (Num):
0.160
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.134
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Branched-chain amino acid metabolism

Denominator Metabolite Explanation:

Fatty acid metabolism, lipid transport

Ratio Explanation:

An increase in this ratio may suggest a shift from fatty acid to amino acid catabolism, potentially influenced by mitochondrial oxidative stress managed by SOD2.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SOD2 function can impact mitochondrial oxidative stress, influencing both lipid and amino acid metabolism, which is reflected in the ratio and linked to cardiovascular diseases and abnormal lipid profiles.4[1], 5[2]

Phenotype Driver:

Gene-centric:SOD2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data