n-acetyl-isoputreanine to 5-methylthioadenosine (mta)

Numerator Metabolite

Structure of n-acetyl-isoputreanine
Metabolite Accession: GCST90200195
Name: n-acetyl-isoputreanine
Hmdb Id: HMDB0094713
Super Pathway: NA
Sub Pathway: NA
Inchikey: YGIAGXACEXFIDU

Denominator Metabolite

Structure of 5-methylthioadenosine (mta)
Metabolite Accession: GCST90200359
Name: 5-methylthioadenosine (mta)
Hmdb Id: HMDB0001173
Super Pathway: NA
Sub Pathway: NA
Inchikey: WUUGFSXJNOTRMR

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.253
Position:
160564476
SE (Ratio):
0.026
Effect Allele:
G
Z-score (Ratio):
9.802
Reference Allele:
C
-log10(P):
-50.555
MAF:
0.175
Beta (Num):
0.138
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.115
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Polyamine metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Methionine salvage, polyamine biosynthesis.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio may reflect SLC22A1 transport activity influencing the balance of polyamine synthesis, where MTA is a byproduct, and catabolism, which produces n-acetyl-isoputreanine.11[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A1 expression alters its transport of substrates like polyamines and thiamine, impacting hepatic lipid and glucose metabolism.2[1], 12[2], 13[3] This metabolic dysregulation, reflected by the ratio, is associated with hypercholesterolaemia and other lipoprotein disorders.1[4], 12[5], 14[6]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data