argininate* to succinylcarnitine (c4dc)

Numerator Metabolite

Structure of argininate*
Metabolite Accession: GCST90199900
Name: argininate*
Hmdb Id: HMDB0003148
Super Pathway: NA
Sub Pathway: NA
Inchikey: BMFMQGXDDJALKQ

Denominator Metabolite

Structure of succinylcarnitine (c4-dc)
Metabolite Accession: GCST90199848
Name: succinylcarnitine (c4-dc)
Hmdb Id: HMDB0061717
Super Pathway: NA
Sub Pathway: NA
Inchikey: HAEVNYBCYZZDFL

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.350
Position:
160564476
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
-14.427
Reference Allele:
C
-log10(P):
-106.976
MAF:
0.175
Beta (Num):
-0.221
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.129
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Urea cycle, nitric oxide synthesis, creatine synthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid oxidation, amino acid catabolism.7[1]

Ratio Explanation:

This ratio may reflect mitochondrial oxidative stress, where SOD2 dysfunction alters arginine-dependent nitric oxide production and mitochondrial substrate handling, indicated by succinylcarnitine.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SOD2 function likely increases mitochondrial oxidative stress, altering arginine and succinylcarnitine levels.3[1], 8[2] This reflects impaired vascular function and energy metabolism, contributing to the development of atherosclerosis and ischemic heart disease, which are associated with lipoprotein metabolism disorders.1[3], 2[4]

Phenotype Driver:

Gene-centric:SOD2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data