2-oxoarginine* to adipoylcarnitine (c6-dc)

Numerator Metabolite

Structure of 2-oxoarginine*
Metabolite Accession: GCST90199903
Name: 2-oxoarginine*
Hmdb Id: HMDB0004225
Super Pathway: NA
Sub Pathway: NA
Inchikey: ARBHXJXXVVHMET

Denominator Metabolite

Structure of adipoylcarnitine (c6-dc)
Metabolite Accession: GCST90200018
Name: adipoylcarnitine (c6-dc)
Hmdb Id: HMDB0061677
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSVHAXJKBCWVDA

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.310
Position:
160564476
SE (Ratio):
0.030
Effect Allele:
G
Z-score (Ratio):
-10.201
Reference Allele:
C
-log10(P):
-54.592
MAF:
0.175
Beta (Num):
-0.149
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.161
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Arginine metabolism, Urea cycle.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, Peroxisomal metabolism.6[1]

Ratio Explanation:

The ratio of 2-oxoarginine to adipoylcarnitine may reflect the balance between arginine catabolism and fatty acid oxidation, potentially influenced by the transporter activity of SLC22A1.4[1], 7[2], 6[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced function of the SLC22A1 transporter is associated with higher levels of LDL cholesterol and triglycerides.8[1], 9[2], 3[3] This may alter the transport of various metabolites, including carnitine derivatives, impacting lipid and energy metabolism, which is consistent with the observed lipoprotein disorder phenotypes.

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data