acisoga to 3-methylglutarylcarnitine (2)

Numerator Metabolite

Structure of acisoga
Metabolite Accession: GCST90199962
Name: acisoga
Hmdb Id: HMDB0061384
Super Pathway: NA
Sub Pathway: NA
Inchikey: OAUYENAPBFTAQT

Denominator Metabolite

Structure of 3-methylglutarylcarnitine (2)
Metabolite Accession: GCST90199971
Name: 3-methylglutarylcarnitine (2)
Hmdb Id: HMDB0000552
Super Pathway: NA
Sub Pathway: NA
Inchikey: HFCPFJNSBPQJDP

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.360
Position:
160564476
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
-13.323
Reference Allele:
C
-log10(P):
-91.570
MAF:
0.171
Beta (Num):
-0.202
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.158
SE (Den):
0.019
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Polyamine catabolism5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Leucine metabolism, Fatty acid metabolism8[1], 9[2], 10[3]

Ratio Explanation:

The ratio of acisoga, a polyamine catabolite, to 3-methylglutarylcarnitine, from leucine/fatty acid metabolism, may reflect altered substrate transport by SLC22A1, impacting cellular energy and lipid balance.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A1 function likely modifies the transport of carnitines and possibly polyamines or their precursors.3[1], 11[2] This altered transport, reflected by the ratio, is associated with dyslipidemia and coronary atherosclerosis, phenotypes also linked directly to SLC22A1 variants' effects on lipid metabolism.1[3], 2[4], 12[5]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data