methylsuccinoylcarnitine to n-acetylarginine

Numerator Metabolite

Metabolite Accession: GCST90200089
Name: methylsuccinoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of n-acetylarginine
Metabolite Accession: GCST90200679
Name: n-acetylarginine
Hmdb Id: HMDB0004620
Super Pathway: NA
Sub Pathway: NA
Inchikey: SNEIUMQYRCDYCH

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.270
Position:
160564476
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
10.130
Reference Allele:
C
-log10(P):
-53.864
MAF:
0.177
Beta (Num):
0.160
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.109
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, energy production.6[1], 7[2], 8[3], 9[4], 10[5]

Denominator Metabolite Explanation:

Arginine metabolism, urea cycle.11[1], 12[2], 13[3], 14[4], 15[5], 16[6], 17[7], 18[8], 19[9], 20[10]

Ratio Explanation:

An elevated ratio may suggest altered SLC22A1-mediated transport of methylsuccinoylcarnitine relative to n-acetylarginine, potentially indicating mitochondrial dysfunction.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A1 function is associated with altered lipid profiles, including higher total and LDL cholesterol.21[1], 22[2], 23[3] The ratio may reflect SLC22A1-related metabolic shifts contributing to dyslipidemia, a key feature of the associated lipoprotein metabolism disorders.

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data