2-oxoarginine* to succinylcarnitine (c4dc)

Numerator Metabolite

Structure of 2-oxoarginine*
Metabolite Accession: GCST90199903
Name: 2-oxoarginine*
Hmdb Id: HMDB0004225
Super Pathway: NA
Sub Pathway: NA
Inchikey: ARBHXJXXVVHMET

Denominator Metabolite

Structure of succinylcarnitine (c4-dc)
Metabolite Accession: GCST90199848
Name: succinylcarnitine (c4-dc)
Hmdb Id: HMDB0061717
Super Pathway: NA
Sub Pathway: NA
Inchikey: HAEVNYBCYZZDFL

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.278
Position:
160564476
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
-11.944
Reference Allele:
C
-log10(P):
-74.046
MAF:
0.175
Beta (Num):
-0.149
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.129
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Arginine metabolism, Urea cycle.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, amino acid catabolism.8[1], 9[2]

Ratio Explanation:

An elevated ratio may indicate altered SLC22A1-mediated transport affecting both arginine/carnitine metabolism, though a direct link is not established.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A1 function may impact hepatic lipid and energy balance by affecting the transport of molecules like carnitine, which is involved in fatty acid oxidation, potentially leading to dyslipidemia.10[1], 11[2], 4[3], 12[4]

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data