n-acetyl-isoputreanine to 2-oxoarginine*

Numerator Metabolite

Structure of n-acetyl-isoputreanine
Metabolite Accession: GCST90200195
Name: n-acetyl-isoputreanine
Hmdb Id: HMDB0094713
Super Pathway: NA
Sub Pathway: NA
Inchikey: YGIAGXACEXFIDU

Denominator Metabolite

Structure of 2-oxoarginine*
Metabolite Accession: GCST90199903
Name: 2-oxoarginine*
Hmdb Id: HMDB0004225
Super Pathway: NA
Sub Pathway: NA
Inchikey: ARBHXJXXVVHMET

Associated Genomic Regions

Region: rs62440901

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
0.313
Position:
160569068
SE (Ratio):
0.031
Effect Allele:
T
Z-score (Ratio):
10.255
Reference Allele:
C
-log10(P):
-55.146
MAF:
0.144
Beta (Num):
0.152
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.162
SE (Den):
0.022
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Polyamine metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Arginine metabolism, Urea cycle.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect a balance between polyamine and arginine metabolism, pathways linked to oxidative stress, which is modulated by the pQTL-associated gene SOD2.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

SOD2 activity influences systemic oxidative stress, a process linked to hypercholesterolemia.10[1], 11[2] Altered SOD2 function may impact arginine and polyamine-related pathways, connecting its genetic signal to lipoprotein metabolism disorders.12[3]

Phenotype Driver:

Gene-centric:SOD2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data