argininate* to methylsuccinoylcarnitine

Numerator Metabolite

Structure of argininate*
Metabolite Accession: GCST90199900
Name: argininate*
Hmdb Id: HMDB0003148
Super Pathway: NA
Sub Pathway: NA
Inchikey: BMFMQGXDDJALKQ

Denominator Metabolite

Metabolite Accession: GCST90200089
Name: methylsuccinoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.381
Position:
160564476
SE (Ratio):
0.026
Effect Allele:
G
Z-score (Ratio):
-14.761
Reference Allele:
C
-log10(P):
-111.859
MAF:
0.175
Beta (Num):
-0.221
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.160
SE (Den):
0.020
No CNV overlap
rQTL cluster:
97
Reaction Distance:
NA
Closest Genes:
SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Urea cycle, amino acid metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Branched-chain amino acid degradation, fatty acid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of an arginine derivative to a BCAA/fatty acid catabolite may reflect mitochondrial stress and altered energy metabolism influenced by SOD2 antioxidant activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SOD2 function likely increases mitochondrial oxidative stress, which impairs fatty acid metabolism and contributes to the observed disorders of lipoprotein metabolism and hypercholesterolaemia.9[1], 1[2], 10[3], 11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:SOD2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data