glutarylcarnitine (c5-dc) to n-acetylarginine

Numerator Metabolite

Metabolite Accession: GCST90199799

Name: glutarylcarnitine (c5-dc)

Hmdb Id: HMDB0013130

Super Pathway: NA

Sub Pathway: NA

Inchikey: NXJAXUYOQLTISD

Denominator Metabolite

Metabolite Accession: GCST90200679

Name: n-acetylarginine

Hmdb Id: HMDB0004620

Super Pathway: NA

Sub Pathway: NA

Inchikey: SNEIUMQYRCDYCH

Associated Genomic Regions

Region: rs662138

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

0.208

Position:

160564476

SE (Ratio):

0.027

Effect Allele:

Z-score (Ratio):

7.799

Reference Allele:

-log10(P):

-32.708

MAF:

0.175

Beta (Num):

0.099

Novel Locus:

Yes ✔️

SE (Num):

0.020

Beta (Den):

-0.109

SE (Den):

0.020

No CNV overlap

rQTL cluster:

Reaction Distance:

Closest Genes:

SLC22A1 SLC22A2 IGF2R SLC22A3 MAS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation

Denominator Metabolite Explanation:

Urea cycle, Arginine metabolism

Ratio Explanation:

The ratio may reflect altered transport of organic cations by SLC22A1, impacting both fatty acid metabolism and arginine homeostasis.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

SLC22A1, as an organic cation transporter, may influence the cellular balance of glutarylcarnitine and N-acetylarginine. Altered transport activity could impact lipid metabolism by affecting fatty acid oxidation and urea cycle function, contributing to hypercholesterolaemia and other lipidaemias.

Phenotype Driver:

Gene-centric:SLC22A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data