gamma-glutamylglycine to n-acetylglycine

Numerator Metabolite

Structure of gamma-glutamylglycine
Metabolite Accession: GCST90199741
Name: gamma-glutamylglycine
Hmdb Id: HMDB0011667
Super Pathway: NA
Sub Pathway: NA
Inchikey: ACIJGUBIMXQCMF

Denominator Metabolite

Structure of n-acetylglycine
Metabolite Accession: GCST90199688
Name: n-acetylglycine
Hmdb Id: HMDB0000532
Super Pathway: NA
Sub Pathway: NA
Inchikey: OKJIRPAQVSHGFK

Associated Genomic Regions

Region: rs35630725;rs1890452

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.174
Position:
76192508
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
9.656
Reference Allele:
G
-log10(P):
-49.127
MAF:
0.337
Beta (Num):
0.097
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.077
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Glutathione metabolism, amino acid transport.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycine metabolism, fatty acid metabolism.7[1], 8[2]

Ratio Explanation:

The ratio may reflect a shift in glycine utilization between glutathione synthesis (gamma-glutamylglycine) and fatty acid conjugation/acetylation pathways (n-acetylglycine), potentially influenced by ACADM activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

A plausible link between ACADM and the ratio exists through fatty acid metabolism's influence on glycine conjugation, but no direct phenotype association is established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data